Understanding the molecular regulation of epithelial-to-mesenchymal transition (EMT) during heart development: novel targets for cardiac regeneration?

Application consists of completing an online application. To apply, please visit the King’s Apply website at https://myapplication.kcl.ac.uk/

We use mouse genetics, human iPSC, and cutting-edge molecular (scRNA- and ATAC-sequencing, CUT&RUN, siRNA library screening) and imaging approaches to gain mechanistic insight into normal heart development to ultimately identify molecular targets to promote regeneration in the (adult) diseased heart. This project focusses on understanding interactions at the epicardium (heart outermost layer)-myocardium interface that support growth and maturation of cardiac muscle, in particular how cells from the epicardium undergo epithelial-to-mesenchymal transition to support organ development and function. This project offers the student a unique opportunity to gain fundamental experience into cardiovascular research and develop wet- and dry-lab research skills.

For further information and how to apply please visit the studentship webpage.