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Understanding the multiple antibiotic resistant ESKAPE pathogen Acinetobacter baumannii


   School of Biosciences

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  Prof David Grainger  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

The ESKAPE pathogens, which evade most commonly used antibiotics, are a small group of bacteria, identified by the WHO in 2017, as presenting the greatest risk to global human health. Amongst these organisms, Acinetobacter baumannii, is an important cause of antibiotic resistant infections acquired in hospitals. Indeed, it is still not understood if A. baumannii has a natural habitat outside of the hospital setting. In addition to escaping the effects of antibiotic treatment, A. baumannii is able to survive for extended periods in the absence of moisture. In a clinical setting, this means that the organism is difficult to eradicate from surfaces. The goal of the project is to understand how A. baumannii can evade antibiotic treatment and other extreme environments. To do this you will use a combination of genomic, genetic, molecular and biochemical tools. You will begin by using genome-wide approaches to understand how A. baumannii responds to extreme environments. It is expected that this approach will identify important genetic determinants for resistance to antibiotics and other extreme conditions. Once key genes are identified, the mechanisms of resistance will be determined at the molecular level.


Funding Notes

Funded by the MIBTP-BBSRC training programme (https://www.birmingham.ac.uk/research/activity/mibtp/index.aspx & https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/) or Darwin Trust scholarship (http://graingerlab.com/opportunities/). Both open to applications worldwide. Differences between home and international fees will not be covered by the MIBTP scheme. State your preferred scheme upon application. For MIBTP-BBSRC, you will need to fill in a University of Birmingham application AND the short notification form on the University of Warwick MIBTP portal. The notification form can be submitted here https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/application/submission/

Further details on the BBSRC MIBTP scheme here: https://www.birmingham.ac.uk/research/activity/mibtp/index.aspx
Deadline: Jan 20th 2023
Studentships available: 30
Stipend: RCUK standard rate (+travel and laptop).
To check eligibility visit: https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/application/#Eligibility

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