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Understanding the nature of sleep disturbances in caregivers for people with dementia with Lewy bodies (Ref: RDF22/HLS/PSY/ELDER)


   Faculty of Health and Life Sciences

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  Dr Greg Elder  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Dementia with Lewy bodies (DLB) is the second most common type of dementia. DLB is a complex and heterogenous disorder, which is characterised by a range of symptoms, including neuropsychiatric symptoms, visuoperceptual difficulties and visual hallucinations.

The challenging, complex and symptom profile of people with DLB can have a significant impact upon their caregivers. DLB places a significant level of burden upon caregivers, and DLB caregivers typically report greater levels of distress than the caregivers of people with Alzheimer’s dementia (AD), or other types of dementia, even when DLB patients have a similar level of cognitive impairment. This has been shown to relate to the presence and severity of patient symptoms.

Caregiver distress is extremely likely to result in DLB caregivers developing sleep disturbances and disorders. A wide range of studies have indicated that stress is associated with subjective and objective sleep disturbances, and that stressful events can predict future sleep disturbances. Indeed, work from dementia caregivers, considered as a whole, demonstrates this: relative to age-matched control non-caregiver adults, caregivers have significant reductions in sleep duration (equivalent to losing up to 3.5 hours of sleep per week) and sleep quality. Additionally, even professional dementia caregivers demonstrate increased levels of stress hormones.

To date, no studies have specifically assessed sleep in DLB caregivers, or the relationship with stress and patient neuropsychiatric symptoms. This is extremely important as given the complex and challenging symptom profile of DLB, DLB caregivers are likely to be at a high risk of developing sleep disturbances and disorders. This is likely to have a direct negative impact upon their health.

Taken together, it is important to understand the nature of sleep disturbances in DLB caregivers. In particular, it is necessary to identify patient events or stressors which may negatively impact upon specific aspects of caregiver subjective and objective sleep. This will allow for the development and testing of bespoke DLB caregiver sleep interventions. This is important as techniques which optimise sleep in this population will benefit individual caregivers, as well as potentially having wider economic and societal benefits.

The specific objectives of this PhD project are to:

  1. to examine, quantify, and compare the nature of subjective and objective sleep disturbances in DLB and AD caregivers
  2. to examine the association between specific patient neuropsychiatric symptoms and DLB caregivers
  3. design a bespoke DLB-specific caregiver intervention to improve sleep, and pilot and test its feasibility and effectiveness.

The project will be supervised by Dr. Greg Elder, Dr. Daniel Rippon and Professor Jason Ellis. The project will be based at Northumbria University and is a collaboration between the Cognition and Communication (Northumbria Sleep Research: Dr. Greg Elder & Professor Jason Ellis) and Health and Wellbeing (Psychobiology, Stress & Wellbeing; Dr. Daniel Rippon) research clusters. Northumbria Sleep Research is fully equipped for a wide range of sleep research studies, including actigraphy watches, and in-lab and ambulatory polysomnography.

Eligibility and How to Apply:

Please note eligibility requirement:

  • Academic excellence of the proposed student i.e. 2:1 (or equivalent GPA from non-UK universities [preference for 1st class honours]); or a Masters (preference for Merit or above); or APEL evidence of substantial practitioner achievement.
  • Appropriate IELTS score, if required.
  • Applicants cannot apply for this funding if currently engaged in Doctoral study at Northumbria or elsewhere or if they have previously been awarded a PhD.

For further details of how to apply, entry requirements and the application form, see

https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/

Please note: Applications that do not include a research proposal of approximately 1,000 words (not a copy of the advert), or that do not include the advert reference (e.g. RDF22/…) will not be considered.

Deadline for applications: 18 February 2022

Start Date: 1 October 2022

Northumbria University takes pride in, and values, the quality and diversity of our staff and students. We welcome applications from all members of the community.

Informal enquiries to Dr Greg Elder ([Email Address Removed]).


Funding Notes

Each studentship supports a full stipend, paid for three years at RCUK rates (for 2021/22 full-time study this is £15,609 per year) and full tuition fees. UK and international (including EU) candidates may apply.
Studentships are available for applicants who wish to study on a part-time basis over 5 years (0.6 FTE, stipend £9,365 per year and full tuition fees) in combination with work or personal responsibilities.
Please also read the full funding notes which include advice for international and part-time applicants.

References

Rippon, D., McDonnell, A., Bristow, M., Smith, M., McCreadie, M. & Wetherell, M., (2021), Elevated Levels of Hair Cortisol Concentrations in Professional Dementia Caregivers, Stress.
Elder, G.J., Colloby, S.J., Firbank, M.J., McKeith, I.G., Taylor, J-P (2019). Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: a randomised controlled trial. Alzheimer’s Research and Therapy, 11 (1), 9.
Elder, G.J., Colloby, S.J., Rowan, E.N., Lett, D., O’Brien, J.T., Anderson, K.N., Burn, D.J., McKeith, I.G & Taylor, J-P (2016). Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies. International Journal of Geriatric Psychiatry, 31 (7), 765 – 70.
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