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Understanding the negative sense RNA intermediate in picornavirus replication

Project Description

Picornaviruses are responsible for a number of serious diseases, including polio and foot-and–mouth disease. There is an urgent need to develop new strategies to address the continuing issue of picornavirus infection. Foot-and–mouth disease virus (FMDV) is an extremely important animal pathogen - the 2001 UK outbreak cost several billion pounds. The project aims to study the features of the viral genome responsible for both rapid replication and persistence, using a replicon system. The long-term aim of the work is to utilise our knowledge of the molecular details of replication in the development of new strategies of disease diagnosis and control.
This interdisciplinary project includes other UK academic institutions as well as the BBSRC Pirbright Institute and will involve close collaboration and research visits.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2020:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference and research funding

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.

EU candidates require 3 years of UK residency to receive full studentship

Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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