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Understanding the regulation and impact of variant splicing in non-small cell lung cancer

  • Full or part time
    Prof P Workman
    Dr P Clarke
  • Application Deadline
    Sunday, November 17, 2019
  • Funded PhD Project (UK Students Only)
    Funded PhD Project (UK Students Only)

About This PhD Project

Project Description

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.

Understanding the regulation and impact of variant splicing in non-small cell lung cancer

Project Description:
There is increasing evidence of an elevated variant splicing burden in many cancers, including non-small cell lung cancer (NSCLC). However, the understanding of the impact of this increased variant splicing on tumorigenesis, treatment and outcome remains limited. The successful applicant will use genetic approaches to identify regulators of variant splicing of mRNAs relevant to NSCLC biology. Candidate hits will be validated and their molecular mechanism of action in regulating splicing explored. The outcome will be a better understanding of factors that regulate splicing in NSCLC and the identification of therapeutic targets for future drug development projects with accompanying splicing biomarkers

Keywords /Subject Areas:
Lung cancer
mRNA processing
Splicing
Target validation

Funding Notes

Stipend, currently £21,000 per annum, tuition fees and project costs paid for the four-year duration. To be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship. Please see the MRC residency requirements for further information.

See icr.ac.uk/phds to apply
Applications close 11:55pm UK time on Sunday 17th November 2019
Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, or Biochemistry.



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