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Understanding the relationship between human genetic ancestry, the gut microbiome and of their modulation of chronic infection in Cape Verde (T2/14)

  • Full or part time
  • Application Deadline
    Thursday, December 05, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Helicobacter pylori (Hp) infection is one of the most common bacterial infections in the world. It is well recognised that Hp infection causes upper gastrointestinal diseases; however, their pathogenesis remains elusive.

The aim of this project to study host genome-microbiome-pathogen interactions affecting Hp infection in Cape Verde. Cape Verdeans derive mixed ancestry from Europe and West Africa, which makes this population ideal to distinguish between environmental and genetic causes of differences in microbiome composition across populations, and their association with susceptibility to Hp infection, because the admixing process brought together human genomes, metagenomes and pathogen strains of diverse origin, thus resembling a natural experiment that randomly exposes human genomes and metagenomes to multiple bacterial strains. This project builds on existing research that characterised the genetic structure of Hp strains in Cape Verde.

The specific goals of this project are: To characterise the genomic variation of (1) ~500 hosts through high-density genotypes; (2) their gut microbiome through 16s rRNA sequencing. To use this data: (1) to analyse the action of host African genetic factors in the composition of the gut microbiome; (2) to evaluate their interplay in infection with Hp (their association with phenotypic variation of the host and Hp).

Entry Requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply.

This project is available for UK/EU/International students.

How to Apply

Application advice and application link:

Funding Notes

This project is funded by the Wellcome Trust Doctoral Training Programme.

Stipend for the PhD: Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997 (rates as of September 2019).

4 year PhD fee waiver at UK/EU rates.

International applicants need to ensure they can fund the difference between UK/EU and international fees for the duration of their studies.

We also will offer 2 fully funded places to international applicants from Lower-middle income countries per year. These will provide a full overseas fee waiver and stipend for 4 years.

Related Subjects

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