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Understanding the role of protein conformation at the nanoscale: In-situ TERS studies of amyloidogenic Tau aggregation

  • Full or part time
  • Application Deadline
    Tuesday, March 31, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Supervisor: Dr Iris Nandhakumar
Co-supervisor Prof. Sumeet Mahajan, Dr Amrit Mudher

Project description

Applications are invited for a prestigious PhD studentship to work on an exciting interdisciplinary project between the Schools of Chemistry and Biological Sciences at the University of Southampton
The project is funded for 4 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in either Chemistry, Biology or related discipline. The project is aimed at understanding the role of protein conformation at the nanoscale which is essential for the early detection, diagnostic screening and the development of preventative therapeutic interventions in diseases such as Alzheimers. To-date the molecular mechanism and the role conformation plays in protein aggregation and toxicity is not well understood. As part of this project the successful candidate will develop novel in situ physico-chemical characterisation tools for assessing protein aggregation. This will be achieved by using surface-enhanced Raman spectroscopy (SERS) executed through the tip of an Atomic Force microscopy (AFM) probe also called tip-enhanced Raman spectroscopy (TERS) which can yield chemical level resolution on single molecules.
If you wish to discuss any details of the project informally, please contact Iris Nandhakumar, Department of Chemistry, Email: , Tel: +44 (0) 2380 59 6877.

Entry Requirements
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).

Closing date: applications should be received no later than 31 March 2020 for standard admissions, but later applications may be considered depending on the funds remaining in place.

Funding: full tuition fees for EU/UK students plus for UK students, an enhanced stipend of £15,009 tax-free per annum for up to 3.5 years.

How To Apply

Applications should be made online here selecting “PhD Chemistry (Full time)” as the programme. Please enter Iris Nandhakumar under the proposed supervisor.

Applications should include:
Research Proposal
Curriculum Vitae
Two reference letters
Degree Transcripts to date
Apply online: https://www.southampton.ac.uk/courses/how-to-apply/postgraduate-applications.page

For further information please contact:

Equality, Diversity and Inclusion is central to the ethos in Chemistry. In recognition of our continued commitment to improving equality for women in science we were awarded an Athena SWAN Silver award in 2014 a and a second Silver award in 2017. Chemistry gives full consideration to applicants that wish to work flexibly including part-time and due consideration will be given to applicants who have taken a career break. The University has a generous maternity policy*, onsite childcare facilities. For further information please visit https://www.southampton.ac.uk/chemistry/about/Equality/index.page

The University of Southampton is in the top 1% of world universities and in the top 10 of the UK’s research-intensive universities. The University of Southampton is committed to sustainability and being a globally responsible university and has recently been awarded the Platinum EcoAward. Our vision is to embed the principles of sustainability into all aspects of our individual and collective work, integrating sustainable development into our business planning, policy-making, and professional activities. This commits all of our staff and students to take responsibility for managing their activities to minimise harm to the environment, whether this through switching off non-essential electrical equipment or using the recycling facilities.
*subject to qualifying criteria

How good is research at University of Southampton in Chemistry?

FTE Category A staff submitted: 44.80

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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