Understanding the role of the globin cytoglobin in cancer cell drug resistance at University of Birmingham on FindAPhD.com

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Dr N J Hodges Applications accepted all year round Self-Funded PhD Students Only

About the Project

Cytoglobin is related to haemoglobin and myoglobin but has a very poorly understood biological function. Work in our lab has shown that expression of cytoglobin in cancer cells alters mitochondrial function and affords protection from anti-cancer drugs including cisplatin. The aim of this project is to further study this and to begin to elucidate the molecular mechanism by which cytoglobin functions. This is important as it may open up opportunities for new ways of over-coming drug resistance in cancer cells.

Techniques you will learn

1) Cell culture including 3D-spheroid cultures
2) General molecular biology (PCR/western blotting)
3) Generation/culture of transgenic cell lines
4) Study of mitochondrial function using a Seahorse XF

Funding Notes

This position is open to self-funded students worldwide with a minimum of a 2.1 degree in Biochemistry or related subject. We are actively seeking funding for this project so funded positions may be available in the future.

References

Nikolos J Hodges, Neal Innocent, Subdha Dhanda, Mark Graham. Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. 2008. Mutagenesis Volume 23, Pages 293-298

Fiona E McRonald, Janet M Risk, Nikolas J Hodges Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. 2012, PLoS One, 7(2) Pages e30587

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University of Birmingham

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Understanding the role of the globin cytoglobin in cancer cell drug resistance

University of Birmingham School of Biosciences