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Understanding the role of the Guanosine Trimethylase TGS1 in Acute myeloid leukaemia

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  • Full or part time
    Dr I Barbieri
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

RNA methylation is a reversible post-translational modification to RNA that epigenetically numerous biological processes. The biological and molecular functions of RNA methylation are generally very poorly understood, both in normal and pathological biological processes.
Recently we identified the RNA Guanosine trimethylase TGS1 as a factor specifically required for the proliferation of Acute myeloid leukaemia cells (AML). Trimethylation of guanosine has been previously reported on Small nuclear non-coding RNAs and on a specific subset of mRNAs. The aim of the project will be to better understand the role of TGS1 and to characterise it as a potential therapeutic target in AML.

Full details of the projects and how to apply are available from the following link:

Interviews will be held during the week commencing 15th April 2019

*Please quote reference PK17049 on your application and in any correspondence about this vacancy.

Funding Notes

The studentships are available to students who qualify for Home/EU fees. Further information at:

Funding will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility with the possibility of additional funding in the fourth year depending on circumstances.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject.
By time of interview all potential students must have fulfilled language requirements for admission.

Applications from ineligible candidates will not be considered.

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