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Understanding the Stability of Biologics Using Advanced Light Scattering Techniques


   Department of Chemical & Biological Engineering


About the Project

The biotherapeutics market was valued at approximately USD 325.17 billion in 2020. It is expected to witness a revenue of USD 496.71 billion in 2026, with a CAGR of 7.32% over the forecast period, 2021-2026. Biotherapeutics (e.g., monoclonal antibodies, recombinant proteins, vaccines etc) are however highly complex molecules, with numerous routes of chemical and physical instability, manifesting from development to manufacturing.

In this project, the candidate will use advanced light scattering techniques to understand the fundamentals of stabilization of biologics, including their degradation mechanisms (e.g., fragmentation and aggregation). This knowledge will then be used to guide bioprocess development and product formulation.

During the project, the candidate will receive training at the interface of engineering and biological sciences. The candidate will gain expertise in the areas of protein science and analytical science. The candidate will also benefit from the resources, supports, and training from the Engineering Graduate School, the Faculty and the Departmental Employability Teams, allowing the candidate to develop themselves into a future leader in bioeconomy.

For more information about the research conducted in Wong and Tee research groups, please visit:

Wong Research Group: https://www.wongbiomanufacturing.com/.

Tee Research Group: https://sites.google.com/sheffield.ac.uk/kanglanteelab/.

Please see this link for information on how to apply: https://www.sheffield.ac.uk/cbe/postgraduate/phd/how-apply. Please include the name of your proposed supervisor and the title of the PhD project within your application.

Applicants must have achieved or expect to achieve a 1st class or 2:1 honours degree or equivalent in a related discipline in Chemical/Biochemical/Environmental Engineering, Bioscience/Microbiology/Molecular Biology or Chemistry. If English is not your first language then you must have an International English Language Testing System (IELTS) average of 6.5 or above with at least 6.0 in each component, or equivalent. Please see this link for further information: https://www.sheffield.ac.uk/postgraduate/phd/apply/english-language.


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