Understanding the transcriptional regulation of BK polyomavirus

As obligate intracellular pathogens, viruses rely on host-cell machinery to facilitate their lifecycle. Nuclear-replicating DNA viruses are exposed to factors that can dictate the transcriptional output of the invading viral genome and ultimately influence infection outcome. Numerous virus families strike a balance between virus replication, host-cell division and successful immune evasion resulting in persistent viral infection.

BK polyomavirus (BKPyV) is a small DNA virus that is highly prevalent in the human population and it establishes a lifelong persistent infection within renal epithelial cells. Clinical disease driven by BKPyV is typically seen in immunocompromised patients, in particular solid-organ transplants such as the kidney. BK nephropathy (BKVAN) can cause serious complications and ultimate lead to graft rejection. Despite its high prevalence in the population and propensity to cause disease in the most vulnerable, there is a lack of knowledge surrounding the host factors that contribute to BKPyV persistence.   

In our lab, we use a range of approaches to identify host factors that necessary for the transcriptional regulation of persistent viral infections. The focus of our work is to identify host factors that are essential for viral persistence during infection. This knowledge could underpin new therapeutic strategies to treat persistent viral infections. 

Person Specification

The Ferguson lab is looking for motivated PhD students interested in host-virus interactions and, specifically, the investigation of factors that are involved in the transcriptional regulation of BK polyomavirus. Applicants should have a strong background in microbiology, ideally with some experience in virology, tissue culture and/or epigenetics. They should have a commitment to molecular virology research and hold or realistically expect to obtain at least an Upper Second-Class Honours Degree (or equivalent) in a relevant subject. 

Applicants are invited from self-funded or scholarship-funded graduates ONLY.

Overseas graduates require IELTs of 6.5 overall.