University of Strathclyde Transformative Technologies for Future Nanomedicines Doctoral Training Centre- Novel Devices for Evaluating Nanomedicine Biological Fate
The highly topical area of nanomedicines refers to the use of engineered nanoscale particles for a broad range of diagnostic and therapeutic applications. While demonstrating significant promise in the laboratory, bench-to-clinic translation has been rather limited. This limited translation is a consequence of gaps in our understanding of nanomedicine interactions in vivo and their impact on safety and efficacy of nanomedicines. Novel measurement pipelines capable of correlating nanomedicine material characteristics with their biological interactions on a plasma, cellular, tissue and systemic level would offer a systematic approach to nanomedicine design from the early product development phase.
This project will evaluate how nanomedicine manufacturing processes contribute to their material characteristics and their fate following interaction with biological matrices. Microengineered devices (using lab-on-a-chip/microfluidic approaches) will be developed to produce new in vitro models for evaluating nanomedicine interactions with biological fluids and measurement of nanomedicine cellular uptake.
We are looking for applicants to join an exciting new interdisciplinary PhD programme as part of Strathclyde’s “Transformative Technologies for Future Nanomedicines” CDT, a collaboration between four Science and Engineering departments at Strathclyde to develop experimental and computational tools and analytical capabilities for evaluating nanomedicines. As a PhD candidate, you will sit at the interface between the Biomedical Engineering department and the Strathclyde Institute of Pharmacy and Biomedical Sciences and will have the opportunity to develop expertise in a wide range of materials science, micro-engineering, imaging and cell biology techniques. As a Strathclyde University PhD candidate, you will also have access to the Strathclyde Researcher Development programme (PG Cert) offering you a competitive advantage as a research professional.
Applicants must have obtained, or expect to obtain, a first or 2.1 UK honours degree, or equivalent for degrees obtained outside the UK, in pharmaceutical sciences, biomedical science, analytical chemistry or a relevant engineering degree. The student should be highly motivated, independent, with strong problem solving abilities and the ability to work as part of a team.
Enquiries and applications should be directed to Dr Rattray ([Email Address Removed]) and Dr Sandison ([Email Address Removed]). Applications will be reviewed and shortlisted candidates will be invited for an interview in early/mid August. It is anticipated that the PhD Studentship will start in October 2019.
All applications must be submitted via email (subject line: PhD applicant) as a single pdf file and include the following:
1) A cover letter (max 1 page) explaining your interest and fit to the project
2) A CV (maximum three pages).
3) Names and contact details of TWO references (including email addresses).
4) A copy of your academic transcripts.
This studentship (available to UK and EU students) will cover full tuition fees and provide a tax-free stipend for 3 years (in line with standard stipend levels).
Barbero F, Russo L, Vitali M, et al. Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System. Seminars in Immunology 2017;34: 52-60.
Bertrand, N., et al. (2017). "Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics." Nature Communications 8(1): 777.
Rattray Z, Rattray NJW, Pluen A (2014). Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation. Trends in Biotechnology 31(8):448-58.