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Unlocking single cell datasets for biomarker discovery in human diseases


Project Description

Recently, single cell gene expression profiling have provided ways to improve the diagnostic measures and risk stratification for many diseases. Precise methods to determine the number and phenotype of cells in disease lesions using small population of cells is of huge importance for the prognosis, diagnosis and discovering the signalling pathways of interest to be targeted by specific therapeutics, in several diseases, including neurological disorders, infections, inflammatory bowel disease, cancers and autoimmune diseases such as rheumatoid arthritis. The goal of this project is to use existing single cell gene expression and other such datasets from various diseases in the literature (and growing) and analyse them in different ways to identify new biomarkers. Single cell gene expression profiling will be implemented to explain the mechanism of disease development and discover new biomarkers by identifying key pathways and constructing networks and sub-networks of co-expressing proteins. The combination of different technologies and statistical analysis will provide novel and more effective methods to identify and validate new disease biomarkers.

ENTRY REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/

Funding Notes

*FUNDING CONFIRMED – Department for the Economy (DfE) Award*

Eligibility for both fees (£4,327 for 2019/20, 2020/21 TBC) and maintenance (£15,009 for 2019/20, 2020/21 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: View Website

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CEM/

When applying, please choose 'MEDICINE' as your subject area/School.

Website for further details about the Lab:
https://pure.qub.ac.uk/en/persons/vijay-tiwari
www.tiwarilab.com

Related Subjects

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