Oxygen and hydrogen isotope fingerprints, derived from local-regional rainfall, can be used to identify the geographical origin of wine. However, the fingerprint varies due to cultivation practices, soil condition, geological characteristics, and loss of the justic power. Deuterium-depleted water (DDW), also known as light water, has less hydrogen isotope, in term of deuterium. DDW can induce healthy effects in biological organisms, such as antioxidant, metabolic detoxification, anticancer, rejuvenation, and behavior. Therefore, DDW has a great potential to be used as post-harvest isotope-depleted marker to label the origin and adulteration of wine. If timeframe is possible we will also undertake a similar analysis with honey.