Unraveling the Impact of Epigenetic and Microenvironmental Factors on Breast Cancer Development and Progression

Breast cancer is a complex disease with multifaceted aetiology, and understanding the processes that regulate disease development and progression is crucial for improving diagnostics and treatment strategies.

Epigenetics plays a pivotal role in regulating gene expression. By investigating how epigenetic alterations impact genes associated with breast cancer, we aim to uncover novel biomarkers and therapeutic targets. Moreover, we aim to explore the interplay between the tumour microenvironment, epigenetics and cancer progression. The supervisory team has a strong track record in using genomics, proteomics, bioinformatics, electrophysiology and patient samples to answer these research questions.

The York Biomedical Research Institute provides access to centralised cutting-edge genomic, single-cell sequencing, high-performance computing and imaging facilities to support the studentship.

Through our research we aim to shed light on the underlying biology of breast cancer, paving the way for more precise diagnostic tools and targeted therapies. This research offers a unique opportunity for students to engage in groundbreaking work with real-world implications, contributing to the ongoing battle against breast cancer.

We enthusiastically welcome applicants interested in both laboratory-based projects and exclusively bioinformatics-based research. The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation, religion/belief, marital status, pregnancy and maternity, or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.