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Unraveling the survival mechanisms of bacteria


Project Description

Bacteria are exposed to a constantly changing environment. Salmonellae are
zoonotic and/or transmitted by an oral-fecal route, and thus need to survive
[and grow] outside their human host as well as inside, exposing them to a
range of stressors and nutrients. However, very little has been done to fully
understand the survival in these differing environments but this insight may
identify new avenues for intervention. In this project the student will use a
combined approach (microbiology, molecular biology, genome mining,
genetics, imaging) to assess the survival mechanism of three pathogenic
Salmonella serovars. The focus will be on assessing the effects of
combinations of subinhibiotry environmentally relevant antibiotics; variable
carbon source and concentration; and single cell to population behavior.
The phenotypes and expression of key genes will be examined, and
supported with genome mining and insights into metabolic and import
pathways, a picture of survival strategies will emerge, enabling the
identification of putative “Achilles heels” for intervention.

The student will be in a supportive open plan laboratory, and supported by a
thesis advisory panel. Opportunities are available to develop broader
skills.(eg outreach, undergraduate teaching (projects, tutorials, grant writing)
Training provided by the Programme is supplemented with lab meetings,
seminars, etc.

Funding Notes

This studentship is fully funded for four years and covers: (i) a tax-free annual stipend at the standard Research Council rate (£15,009 estimated for 2020 entry), (ii) research costs, and (iii) tuition fees at the UK/EU rate.

References

Entry requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this research project means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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