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Use of nanoparticles for vascular delivery of immunomodulatory drugs in cardiovascular diseases


   College of Medicine, Veterinary and Life Sciences

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  Dr P Maffia, Prof T Guzik  No more applications being accepted  Funded PhD Project (UK Students Only)

Glasgow United Kingdom Immunology

About the Project

Supervisors:

Dr Pasquale Maffia 

Prof Tomasz Guzik 

PhD Project Summary:

Immune responses play a critical role in cardiovascular diseases (CVD) development; however, immunomodulatory therapies are not used routinely to treat CVD, reflecting in part, concerns about systemic immune suppression given the necessity for chronic therapeutics. Nanotechnology can potentially deliver drugs selectively to inflamed vessels avoiding systemic exposure. Recently, we have used lipid-based nanoparticles for targeted drug delivery of methotrexate to the atheroma. Herein we will employ a novel microfluidics-based method to produce lipoprotein-mimicking nanoparticle carrier vehicles to selectively deliver immunomodulatory drugs to atherosclerotic and hypertensive arteries. We will incorporate appropriate detection moieties e.g. fluorochromes into nanoparticles, to enable their localisation by various imaging modalities. Thereafter, we will evaluate the anti-inflammatory impact of locally delivered immunomodulators in vitro in complex vascular cell culture and in vivo in validated murine models of cardiovascular disease.


Funding Notes

The studentship provides funding for tuition fees, a stipend and laboratory expenses for Home (UK) applicants only.
The MVLS/EPSRC grant provides tuition fees and stipend of at least £15,285 (UKRI rate 2020/21).
Please view application information here: https://www.gla.ac.uk/colleges/mvls/graduateschool/mvlsepsrcstudentships/
Once you have all the required application documentation, please apply here: https://www.gla.ac.uk/study/applyonline/?CAREER=PGR&PLAN_CODES=ZY38-7316