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Using Dynamic Combinatorial Selection Methods to Identify Chemical Modifications of Protein Function


   Faculty of Engineering and Physical Sciences

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  Prof A J Wilson, Prof S E Radford  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

Leeds United Kingdom Biochemistry Biophysics Organic Chemistry Pharmaceutical Chemistry Structural Biology

About the Project

This PhD studentship will exploit chemical biology approaches to understand and manipulate the aggregation behaviour of α-synuclein, an intrinsically disordered protein which plays a key role in the neurodegenerative condition: Parkinson's disease. We will apply a state of the art combination of peptide and protein chemistry, fragment based ligand discovery methods and advanced biophysical techniques and structural methods to identify modifications to the sequence of α-synuclein and systematically map the consequences for its aggregation behaviour in vitro and in cells.


Funding Notes

A highly competitive BBSRC Doctoral Training Partnership Studentship consisting of the award of fees with a maintenance grant (currently £15,609 for session 2021/22) for 4 years. This opportunity is open to all applicants. Selection is based on academic merit.
The award also includes: Research Training and Support Grant (RTSG); Conference and Professional Internships for PhD Students (PIPS) allowances; and Centrally organised training and networking opportunities, including an annual student symposium.  
Please refer to the UKCISA website for information regarding Fee Status for Non-UK Nationals starting from September/October 2021.
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