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Using genetic data to identify and characterise subtypes of asthma to inform drug development and precision medicine


   Department of Health Sciences

  , ,  Wednesday, December 01, 2021  Competition Funded PhD Project (Students Worldwide)

Leicester United Kingdom Bioinformatics Data Analysis Genetics Health Informatics Statistics

About the Project

Wellcome Trust Studentship

Project:

Asthma is a condition affecting over 300 million people worldwide. It is now recognised that there are different types of asthma (also called subtypes) with distinct causal mechanisms, and different responses to therapies. For example, approximately 5% of individuals with asthma have severe forms of asthma that do not respond to any currently available treatments.

The aim of this project is to use genomic and phenotype data from a large population-based cohort (the UK Biobank) to identify potential subtypes of asthma. This will involve exploring (and potentially helping to develop) cutting-edge methods for dimension reduction of variant-trait association matrices. These subtypes will then be validated and characterised in asthma patients from asthma-specific cohorts such as GASP and RASP-UK. This work has the potential to inform development of new therapies for treatment-unresponsive asthma and the targeting of existing therapies to patients most likely to respond.

The studentship will be based within an internationally-recognised genetic epidemiology group at the University of Leicester offering excellent training in statistical genetics and genetic epidemiology, bioinformatics, and health data science. The student will be co-supervised by experts in the clinical aspects of asthma and will have the opportunity for placements at the University of Nottingham and with industrial partners.

Additional Information

  • Open to UK and International Students.
  • 4 year Competition Funded
  • Candidates applying to the 4-year PhD should hold or expect to hold an undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
  • Start date September 2022
  • Closing date for applications 11:59pm 1 December 2021.

For full details of the PhD Studentship, application advice and link to the application system please refer to https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust. CVs submitted via the enquiry form below will not be accepted.


Funding Notes

4 Year competition funding
• Postgraduate research fee waiver at standard College of Life Sciences UK rates for all four years of the PhD
• Wellcome Trust stipend for all four years of the PhD ( Wellcome Trust stipend rates: PhD Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997.)
• International students who are not from an identified LMIC are welcome to apply but may be required to pay the difference between home student fees and international student fees for the duration of their studies.

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