Faculty of Biology, Medicine and Health

The University of Manchester

  Using genomic technologies to determine circadian regulation of psoriasis (Sep 25 entry)

  , ,  Sunday, June 15, 2025  Funded PhD Project (UK Students Only)

About the Project

Circadian control of inflammation is emerging as an exciting field, with immediate translation potential. Psoriasis represents a model of immune-mediated inflammation in which the pathology is accessible and amenable to serial investigation. Determining how the clock couples to the immune system, and the involvement of clock outputs in psoriasis pathogenesis, will identify novel therapeutic targets for the treatment of psoriasis and other inflammatory disorders.

Objective: To interrogate the hypothesis - Psoriasis disease is driven by the circadian clock, through inflammatory cytokine circuits, with implications for personalised medicine, and chronotherapy - in order to build an evidence-base for circadian therapeutic trials in psoriasis.

Training. Based at The University of Manchester, this project draws on a world-class psoriasis treatment, and research centre, co-located with a major circadian biology centre. We have assembled an interdisciplinary team, including clinical investigators (HY and DR), computational biologists (MI), and circadian inflammation expertise (DR). Our genomics work will be delivered through the MRC-funded Single Cell Research Centre. We have clinical care, clinical investigation, wet-lab, and genomics all delivered on the same campus. This project benefits from BRC infrastructure support, which will enable it to succeed.

Applicants are expected to hold (or about to obtain) a minimum upper second class undergraduate honours degree (or equivalent) in biomedical sciences / biochemistry / genetics.  Experience in computational biology / bioinformatics and molecular biology is desirable. 

How to Apply

For information

on how to apply for this project, please visit the Faculty of Biology, Medicine

and Health Doctoral Academy website

(https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries

may be made directly to the primary supervisor. 

Equality, Diversity & Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/

Biological Sciences (4) Mathematics (25) Medicine (26)

Register your interest for this project



Where will I study?

Faculty of Biology, Medicine and Health

Tackle real world challenges, make a difference, and elevate your career with postgraduate research in the Faculty of Biology, Medicine and Health at Manchester. From biochemistry to neuroscience, cancer sciences to medicine, audiology to mental health and everything in between, we offer a wide range of postgraduate research projects, programmes and funding which will allow you to immerse yourself in an area of research you’re passionate about.

Why study at Faculty of Biology, Medicine and Health?

Ranked the best place to live in the UK (The Economist Global Liveability Index, 2022), Manchester boasts world-class culture, iconic sports, a thriving music and food scene, and much more. It's not just a place to research, it's a place to call home.

Experience PhD life as part of a diverse postgraduate research community of more than 1,000 postgraduate researchers at the 29th most international university in the world (Times Higher Education, 2023).

With 93% of research activity at the University rated as 'world-leading' or 'internationally excellent' (Research Excellence Framework, 2021), you'll get the chance to have an impact on global health and science challenges.

1000+

postgraduate students

90

PhDs

6

ranked in UK - QS (2025)

Manchester  United Kingdom

main campus

About Faculty of Biology, Medicine and Health

At Manchester, postgraduate researchers are at the heart of our mission to tackle pressing global challenges in biological, medical and healthcare sciences - and you could be too.

By choosing Manchester for your postgraduate research, you’ll be joining a university with an exceptional research reputation, where 93% of research is world-leading or internationally excellent (REF, 2021) and where your work will have real-world impact.

You’ll research in world-class facilities alongside leading experts at the forefront of innovation, collaborating across disciplines to pioneer new treatments, advance scientific knowledge, and improve healthcare globally.

Supported by our dedicated Doctoral Academy and strong industry links, you'll experience PhD life in a vibrant, welcoming and diverse postgraduate research community.

And you’ll leave with the specialist knowledge, research experience and transferable skills that will shape your future in academia, research or industry.


Main campus

The University of Manchester

Manchester

North West

United Kingdom

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