About the Project
Circadian control of inflammation is emerging as an exciting field, with immediate translation potential. Psoriasis represents a model of immune-mediated inflammation in which the pathology is accessible and amenable to serial investigation. Determining how the clock couples to the immune system, and the involvement of clock outputs in psoriasis pathogenesis, will identify novel therapeutic targets for the treatment of psoriasis and other inflammatory disorders.
Objective: To interrogate the hypothesis - Psoriasis disease is driven by the circadian clock, through inflammatory cytokine circuits, with implications for personalised medicine, and chronotherapy - in order to build an evidence-base for circadian therapeutic trials in psoriasis.
Training. Based at The University of Manchester, this project draws on a world-class psoriasis treatment, and research centre, co-located with a major circadian biology centre. We have assembled an interdisciplinary team, including clinical investigators (HY and DR), computational biologists (MI), and circadian inflammation expertise (DR). Our genomics work will be delivered through the MRC-funded Single Cell Research Centre. We have clinical care, clinical investigation, wet-lab, and genomics all delivered on the same campus. This project benefits from BRC infrastructure support, which will enable it to succeed.
Applicants are expected to hold (or about to obtain) a minimum upper second class undergraduate honours degree (or equivalent) in biomedical sciences / biochemistry / genetics. Experience in computational biology / bioinformatics and molecular biology is desirable.
How to Apply
For information
on how to apply for this project, please visit the Faculty of Biology, Medicine
and Health Doctoral Academy website
(https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries
may be made directly to the primary supervisor.
Equality, Diversity & Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
Register your interest for this project
The university will respond to you directly. You will have a FindAPhD account to view your sent enquiries and receive email alerts with new PhD opportunities and guidance to help you choose the right programme.
It looks like you alredy have a FindAPhD Account
Log in to save time sending your enquiry and view previously sent enquiries
The information you submit to The University of Manchester will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

Search suggestions
Based on your current searches we recommend the following search filters.
Check out our other PhDs in Manchester, United Kingdom
Start a New search with our database of over 4,000 PhDs

PhD suggestions
Based on your current search criteria we thought you might be interested in these.
Developing “intelligent” information technologies using neural markers of multisensory decision-making and learning
University of Leeds
On-Demand Regulation of the Transcriptional Activity of Redox Induced Transcription Factors in Cancer Using Bioelectronics
The University of Manchester
UAV Obstacle Avoidance Using Learning algorithm and Stochastic Regulation
Edinburgh Napier University