Don't miss our weekly PhD newsletter | Sign up now Don't miss our weekly PhD newsletter | Sign up now

  Using pharmacological agents to investigate the mechanisms of the neuronal vascular coupling


   School of Psychology

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The changes in cerebral blood flow, volume and oxygenation that accompany increases in neural activity form the basis of non-invasive neuroimaging techniques such as blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) which allow human brain mapping. Understanding the relationship between cerebral hemodynamics and the underlying evoked neural activity is therefore vital for the interpretation of neuroimaging data. With a unique combination of optical, electrophysiological and MR techniques in a rodent model we have previously explored the quantitative relationships between increases in activity and the accompanying hemodynamics and positive fMRI signals. In this project we will investigate the chemical mediators and mechanisms of neurovascular coupling by using specific pharmacological blockers thought to play a role in the coupling process.
Research Groups Involved: Dr Jason Berwick, Dr Myles Jones, Dr Aneurin Kennerley, Dr Ying Zheng. Dr CHUANG Kai-Hsiang – Singapore Bioimaging consortium
Biological Sciences (4) Psychology (31)

Funding Notes

Self funded or externally sponsored students only. Intakes are usually October and March annually.

NB The University has some scholarships under competition each year. More details can be found - View Website

Register your interest for this project



How good is research at University of Sheffield in Psychology, Psychiatry and Neuroscience?


Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities