About the Project
The project will involve proteomic analysis of the biomarker candidates using Multiple Reaction Monitoring Mass Spectrometry in collaboration with the centre for proteome research, manipulation of the chick embryo model to study tumorigenesis and perform drug testing, immunostaining and imaging of the tumours and functional analysis of drug efficacy by measuring cell proliferation, apoptosis, cell differentiation, gene expression… It is a multidisciplinary project with clinicians, who will provide access to tumour samples and biobank.
The training will include a range of techniques such as basic molecular and cell biology techniques including molecular cloning, tissue culture, the chick embryo model, protein and mRNA expression measurements, cell survival assay and gene expression. In addition, the student will also receive a strong training in proteomic and microscopy within the Liverpool Centres for Proteome research and for Cell Imaging. The supervisory team, which includes scientists and clinicians will closely mentor and train the students whilst providing the opportunity to develop their own ideas. The student will also be trained in scientific communication skills by presenting their work at lab meetings, international conferences and during poster presentations.
Assistance will be given to those who are applying to international funding schemes. The successful applicant will be expected to provide the funding for tuition fees and living expenses as well as research costs of £3000 per year.
Details of costs can be found on the University website: View Website
To apply send a CV and cover letter to firstname.lastname@example.org
Herrmann, A., Moss, D., & Sée, V. (2016). The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis.. In Tumour Angiogenesis AssaysBook (Vol. 1464, pp. 97-105). doi:10.1007/978-1-4939-3999-2_9
Swadi, R., Mather, G., Pizer, B. L., Losty, P. D., See, V., & Moss, D. (2018). Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery. BMC CANCER, 18. doi:10.1186/s12885-017-3978-x
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