Tissue engineering strategies have created a large number of functional tissues constructed from cells and matrix components over the past two decades. Many of these tissues have enhanced our understanding of cell-extracellular matrix interactions and provide an impressive resource for future scientific endeavor. However, the ability to maintain ex vivo and implant large engineered tissues is limited by the ability to perfuse those tissues with nutrients and remove waste products. This is the role of the vasculature in vivo and this project looks to mimic this through tissue engineering strategies, in a validated 3D model of skeletal muscle. This project will combine tissue engineering, additive manufacture and cell biology to generate a vascularized, perfusable skeletal muscle suitable for long term ex vivo culture and potential implantation.
- Applicants should have, or expect to achieve, at least a 2:1 honours degree (or equivalent) in sport and exercise science, human physiology, human biology, biochemistry or a related subject. A relevant master’s degree and/or experience in one or more of the above subjects will be an advantage. - All students must also meet the minimum English Language requirements - A relevant master's degree and / or experience in one or more of the following will be an advantage: Human biology, exercise physiology, biochemistry