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Viral hijacking of host factors

  • Full or part time
  • Application Deadline
    Thursday, February 21, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Viruses are small organisms that are not even considered alive by many, and are only able to procreate within a host cell. In order to do so, they must "hijack" the biochemical apparatus of the host cell and remodel it to serve viral replication. For instance, picornaviruses use their small non-structural protein 3A to hijack the lipid kinase PI4KB and remodel Golgi or ER membrane into viral replication platform.

Structural biology (X-ray crystallography, small angle X-ray scattering and protein NMR) and various biophysical techniques (fluorescence, liposome reconstitution, analytical ultracentrifugation) in combination with confocal microscopy will be used to gain deep understanding of viral replication on the surface of host membranes and to reconstitute replication of selected viruses in vitro. (http://www.uochb.cz/infochem/boura)

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries

All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

Related Subjects

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