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Virus manipulation of a host cell micro-RNA regulates gene expression in viral replication and transformation

Faculty of Biological Sciences

Leeds United Kingdom Cancer Biology Genetics Virology

About the Project

Micro-RNAs (miRNAs) are abundant endogenous RNAs and emerging evidence suggests they regulate gene expression by multiple processes. As such, miRNAs may play a central role in regulating a wide variety of biological processes and dysregulation of miRNAs expression may be implicated in human disease.We have exciting preliminary data suggesting that miRNA expression is manipulated by HPV to regulate downstream host signalling. This suggests that virus-mediated miRNA dysregulation plays a fundamental and essential role in regulating virus and host cell gene expression required for viral pathogenesis and transformation. The aim of this project is to determine how virus-mediated manipulation of host cell miRNAs regulate both virus and host cell gene expression during virus infection. Moreover, the project will identify novel host factors which regulate HPV replication and transformation, highlighting potential therapeutic approaches for the treatment of this important virus. The project will utilise a multidisciplinary approach involving cutting-edge techniques including mIR-seq profiling coupled with NGS analysis, bioinformatic analysis, confocal imaging and cell biology and use of physiological model cell culture systems.

Funding Notes

The Emma and Leslie Reid Scholarship is also available to Home fee-rated applicants. This award will cover fees at the University of Leeds standard rate and a maintenance grant at a rate of £14,000 for 3 years. Information on how to apply is via the following link: View Website

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