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Want to do a PhD on chromatin biology and epigenetics in malaria parasites? Come join us in Hamburg!


About This PhD Project

Project Description

Who we are:
We are a newly established group at the Centre for Structural Systems Biology (CSSB) in Hamburg, Germany. Our lab is interested in everything related to long non-coding RNA biology, epigenetics and chromatin structure in the malaria parasite Plasmodium falciparum. The particular focus of our research is to elucidate, how the parasite uses these mechanisms to control cellular differentiation throughout its life cycle.

Who we are looking for:
We are looking for a highly motivated and team-oriented PhD student with strong communication skills. The candidate should have an extensive background in cell and molecular biology, with a master’s degree in molecular cell biology, chromatin biology, biochemistry, or an equivalent discipline.

What we offer:
We offer a fully funded position and the possibility to work on an exciting and intellectual challenging project in the field of P. falciparum chromatin biology and epigenetics. The candidate will have the opportunity to use cutting-edge technologies ranging from CRISPR/Cas9 based genome editing and super resolution microscopy, to deep-sequencing methods like RNA-seq and ChIP-seq approaches.
Our lab is located in the brand new CSSB building on the DESY campus in Hamburg. The institute brings together labs from ten different research institutions and provides a lively and collaborative research environment with access to world-class core facilities and outstanding resources and support.

How to apply:
If you are interested in joining our lab and pursuing a few years of science here in Hamburg, please send a single PDF file comprised of a cover letter, CV, a one-page statement about your motivation and research accomplishments and contact information for three references to:

References

GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing.
Filarsky M, Fraschka SA, Niederwieser I, Brancucci NMB, Carrington E, Carrió E, Moes S, Jenoe P, Bártfai R, Voss TS.
Science. 2018 Mar 16;359(6381):1259-1263. doi: 10.1126/science.aan6042.
PMID: 29590075

Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites.
Fraschka SA, Filarsky M, Hoo R, Niederwieser I, Yam XY, Brancucci NMB, Mohring F, Mushunje AT, Huang X, Christensen PR, Nosten F, Bozdech Z, Russell B, Moon RW, Marti M, Preiser PR, Bártfai R, Voss TS.
Cell Host Microbe. 2018 Mar 14;23(3):407-420.e8. doi: 10.1016/j.chom.2018.01.008. Epub 2018 Mar 1.
PMID: 29503181

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