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Watching cancer metastasise live and investigating the underlying mechanisms


Project Description

Cancer metastasis accounts for around 90% of cancer deaths. While the survival rate has been improved over the years through early diagnosis, limited progress has been made in the targeting of metastasis. This stems from a fundamental lack of understanding of the basic biology underlying this process. While flies have emerged as powerful tool to investigate tumour growth and identify cancer related pathways, to-date studies have been limited by a lack of metastatic models where cells can be followed from primary tumour development to secondary tumour formation in adult organisms. We recently overcame this longstanding limitation, developing the first model for the induction of macrometastases in adult Drosophila melanogaster.

This project aims to now leverage this model to identify the cellular and molecular mechanisms that underlie the first steps of cell dissemination from the primary tumour. This will involve developing methods to live image tumour cell dissemination from primary tumours, out of a complex organ, on our labs own dedicated multiphoton confocal. In parallel, genomics data existing within the lab will be mined to identify candidate genes. Combining live and fixed confocal analysis, as well as sensitive luciferase assays for each step of the metastatic process, these candidates will be investigated for a functional role in tumour metastasis. Overall, we expect the findings from the project to provide new insight into the complex process of cancer metastasis, as well as provide novel prognostic and therapeutic markers for metastatic colorectal cancer.

Science Graduate School
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more.

Funding Notes

This position is open to self-funded students

First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University's application form using the following link: View Website Candidates with experience with Drosophila or with an interest in disease modelling in Drosophila are encouraged to apply.

All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information.

References

https://cellplasticity.weebly.com

https://www.sheffield.ac.uk/bms/research/campbell

Campbell, K.*,Rossi, F., Adams, J., Pitsidianaki, I., Barriga, F., Garcia-Gerique, L., Batlle, E., Casanova, J. and Casali A.*. (2019). Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. Nat Commun doi: 10.1038/s41467-019-10269-y.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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