Additional Supervisor: • Prof Melanie Madhani, University of Birmingham
Embark on an exhilarating journey at the forefront of cardiovascular research by joining this cutting-edge PhD program in collaboration with the University of Birmingham, specifically focused on the dynamic interplay of Reactive Sulfur Species (RSS) in the aftermath of acute myocardial infarction (AMI). AMI, a global health concern, triggers a cascade of events, including inflammatory responses that impact cardiac function. Led by world-renowned experts Prof Madhani and Dr Switzer, our research explores the enigmatic role of RSS in this critical scenario. Prof Madhani's discovery of RSS in oxygen-deprived cardiac cells sets the stage, while Dr Switzer's revelations of the dual nature of RSS, possessing both cyto-protective and pro-inflammatory attributes, add an intriguing dimension to whether RSS can influence the inflammatory response after AMI. Cutting-edge techniques, such as live cell imaging and mass spectrometry, will unveil the impact of RSS on inflammatory signalling and gene expression in cardiac cells. The anticipated outcomes of this ground-breaking research will not only enrich our understanding of RSS but also pave the way for transformative strategies to mitigate tissue damage in myocardial infarction patients. You will contribute to unravelling the secrets of an unexplored realm in redox biology, making a lasting impact on cardiovascular science.
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