What is the role of Reactive Sulfur Species in myocardial infarction-induced inflammation?


   Molecular and Cell Biology

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  Dr Christopher Switzer  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Additional Supervisor: • Prof Melanie Madhani, University of Birmingham

Embark on an exhilarating journey at the forefront of cardiovascular research by joining this cutting-edge PhD program in collaboration with the University of Birmingham, specifically focused on the dynamic interplay of Reactive Sulfur Species (RSS) in the aftermath of acute myocardial infarction (AMI). AMI, a global health concern, triggers a cascade of events, including inflammatory responses that impact cardiac function. Led by world-renowned experts Prof Madhani and Dr Switzer, our research explores the enigmatic role of RSS in this critical scenario. Prof Madhani's discovery of RSS in oxygen-deprived cardiac cells sets the stage, while Dr Switzer's revelations of the dual nature of RSS, possessing both cyto-protective and pro-inflammatory attributes, add an intriguing dimension to whether RSS can influence the inflammatory response after AMI. Cutting-edge techniques, such as live cell imaging and mass spectrometry, will unveil the impact of RSS on inflammatory signalling and gene expression in cardiac cells. The anticipated outcomes of this ground-breaking research will not only enrich our understanding of RSS but also pave the way for transformative strategies to mitigate tissue damage in myocardial infarction patients. You will contribute to unravelling the secrets of an unexplored realm in redox biology, making a lasting impact on cardiovascular science.

Enquiries

Project Enquiries to [Email Address Removed]

Programme enquiries to [Email Address Removed]

To apply please refer to

https://more.bham.ac.uk/mrc-aim/phd-opportunities/


Biological Sciences (4) Chemistry (6) Engineering (12) Mathematics (25) Medicine (26)

Funding Notes

The competition funding provides students with:
4 years of stipend at UKRI rates
4 years of tuition fees at UK fee rates (Plus one award of a full overseas fee waiver to an international applicant)*
RTSG
Budget to help with the cost of purchasing a laptop
The University of Leicester will provide full overseas fee waivers for the duration of their study to all international students accepted at Leicester. The funder, UKRI, allows us to appoint up to 30% overseas students.

References

C. H. Switzer, J. M. Fukuto. The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species. Redox Biology 57, 102486 (2022).
C. H. Switzer. How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology. Redox Biology 67, 102899 (2023).
C. H. Switzer, S. Kasamatsu, H. Ihara, P. Eaton. SOD1 is an essential H2S detoxifying enzyme. Proceedings of the National Academy of Sciences 120, e2205044120 (2023).
K. Griffiths et al. Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? Redox Biology 60, 102605 (2023).