About the Project
At present, there is considerable variation in the type of therapeutic interventions offered to patients with stroke aphasia for their anomia. One popular approach, as represented in a number of recently developed computerised therapy packages, is to adopt a multimodal approach, where the patient is presented with information about the meaning of a word, the pronunciation of word, and the articulatory gestures to produce the word (e.g., Sandars et al., 2017). The logic behind this approach is some aspect of the therapy will work to remediate the root cause of the anomia, and other aspects could strengthen this effect. We have recently acquired data that has indicated that, for some patients with a particular lesion profile, the multimodal approach is actually less effective than one that focusses on specific aspects. This project will use structural and functional imaging to predict patient response to multimodal vs unimodal therapies. In doing so, it will allow us to tailor therapy for anomia to the individual patient based upon their lesion profile, optimising its effectiveness.
Training/techniques to be provided:
This project will involve training in case series neuropsychological assessment and analysis, experience of working with clinical populations with communication impairments, creation of therapeutic intervention and analysis of gains, acquisition, processing and analyses of multimodal imaging data relating to brain integrity, connectivity and function, and techniques to relate behaviour and imaging data.
Candidates are expected to hold a minimum upper second class honours degree (or equivalent) in a relevant subject area, which includes psychology, neuroscience or speech and language therapy, and candidates with a medical degree will also be considered. Candidates with experience in neuroimaging analysis and/or working with patients with neurological impairments or with an interest in the neural basis of and treatment for language disorders are encouraged to apply. Informal enquiries may be made directly to the primary supervisor.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Butler, R.A., Ralph, M.A.L., Woollams, A.M. (2014). Capturing multidimensionality in stroke aphasia: Mapping principal behavioural components to neural structures. Brain, 137, 3248-3266.
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