About the Project
This interdisciplinary project will provide training opportunities in many techniques spanning chemistry and biology, including synthetic chemistry, the culture of fungi, biochemical methods and mass spectrometry-based proteomics. You will develop compounds into chemical tools to discover the protein targets that they interact with in cells to exert their bioactivity. You will also use quantitative proteomics to assess the impact of different fungicides on the proteome, producing a dataset that can be mined for mode of action “signatures” of novel compounds.
This project will be jointly supervised by Drs Wright and Webb, who bring expertise in chemical proteomics, organic and biological chemistry, in the School of Chemistry at the University of Leeds, and Drs Thacker and Sinclair at Syngenta Group, experts in fungicide bioscience and proteomics respectively. Two short placements at Syngenta will provide an excellent opportunity to gain insight into work in the agrochemical industry. We are seeking a talented and motivated PhD student with a background in chemistry/biochemistry and an interest in working at the chemistry-biology interface.
4 year fully-funded integrated research and skills training programme, starting October 2021:
• Research Council Stipend (estimated £15,600 per year)
• Tuition fees at the UK fee rate (£4,473 per year)
• Research training and support grant
Please note: international tuition fees for 2021 entry are £23,750
At least a 2:1 honours degree or equivalent. We welcome students with biological, chemical or physical sciences, or
mathematical backgrounds interested in biological questions.
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