mRNA technology has recently demonstrated the ability to significantly change the timeline for developing and delivering a new vaccine from years to months, highlighted by the successful development and approval of two mRNA vaccines for COVID-19.
The development of new tools/technologies for the analysis of mRNA therapeutics is critical to underpin manufacturing and the development of new mRNA therapeutics/vaccines.
Direct RNA sequence mapping is a powerfull new method utilised for the characterisation of mRNA therapetucs. However, there are limited RNase enzymes that can be used, limiting the application of such methods for the characterization of mRNA. It is proposed to develop a toolbox of RNA restriction enzymes based on the MazF endonucleases from different organisms that exhibit different sequence specificities.
Training will be provided in a wide range of state of the art equipment including HPLC/UHPLC, mass spectrometry, capillary electrophoresis, protein expression and purification.
About the DTP
This studentship is offered as part of the White Rose BBSRC Doctoral Training Partnership (DTP) in Mechanistic Biology, which brings together the research of the world-class molecular and cellular bioscience centres at the White Rose universities of Leeds, Sheffield and York.
Our mission is to train excellent bio-scientists who understand how living systems work and can innovate to address global challenges, such as the impact of climate change, a healthier old age, sustainable food production, land use and energy production.
What is on offer?
This is an i-CASE (industry partnership) studentship for entry in October 2024.
Join us and you will receive a 4-year, funded PhD programme of research and skills training, with cross-disciplinary supervision, plus a structured programme of cohort-wide training and networking events. A highlight is the annual symposium, which is planned and delivered by students.
A unique part of your training will be a fully-funded placement of at least 3 months with the industry partner.
How to apply – Expression of Interest
Students may apply for up to three projects anywhere in the Doctoral Training Partnership (DTP). Applications will be to the DTP centrally, using an online Expression of Interest (EoI). The EoI will include:
§ CV information; not submitted separately
§ Equality, Diversity and Inclusion (EDI) data
§ Names of two referees
Deadline for EoIs is midnight Sunday 7th January 2024.
Submit EoIs using this link: https://leeds.onlinesurveys.ac.uk/white-rose-bbsrc-dtp-expression-of-interest-form
Shortlisted candidates will be required to make formal applications to the Graduate School at each institution, supplying the necessary paperwork.
Details of the interview process will be decided by the academic and industry partners for this project