Join the Nanopore Sequencing Revolution
Ready to dive into ground-breaking DNA sequencing research? Recent advances in DNA sequencing are revolutionizing fields like medicine, healthcare, food supply chains, and environmental safety. At the heart of this revolution is nanopore sequencing, a cutting-edge technique using 1nm pores in a membrane to detect electrical signals as DNA bases pass through.
But here's the exciting part: We're pushing the boundaries of nanopore sequencing by harnessing bioinspired protein nanopores. These ultra-sensitive structures can enhance reliability and prolong pore lifespan. Oxford Nanopore Technologies (ONT) already achieves 99% sequencing accuracy, but we aim to merge the membrane pore and helicase into a single protein for a sequencing revolution.
How? We're pioneering direct membrane insertion of hexameric helicases to improve translocation speed and pore stability.
Why Choose this Project: Your Path to Innovation
This is an invitation to join an interdisciplinary collaboration spanning molecular biology, protein biochemistry, structural biology, and single-molecule biophysics. You'll straddle academia at the University of York and industrial biotechnology R&D at ONT. Plus, we're partnering with Dr. Sanders' lab at the University of Sheffield for helicase characterization.
Financial Support for Your Ambitions
This fully funded opportunity includes a BBSRC stipend, ONT supplement, and funding for your ONT placement. Picture yourself in a dynamic research environment with renowned academics and entrepreneurs. Under ONT's guidance, you'll explore industrial potential and cross-disciplinary collaboration.
Your Launchpad for the Future
At the University of York, you'll participate in world-class academic research, setting your foundation for a future in academia, industry, or start-ups.
Ready for a scientific revolution in DNA sequencing? Join us on this journey where your passion meets the potential of nanopore sequencing. Apply now to shape the future!
About the DTP
This studentship is offered as part of the White Rose BBSRC Doctoral Training Partnership (DTP) in Mechanistic Biology, which brings together the research of the world-class molecular and cellular bioscience centres at the White Rose universities of Leeds, Sheffield and York.
Our mission is to train excellent bio-scientists who understand how living systems work and can innovate to address global challenges, such as the impact of climate change, a healthier old age, sustainable food production, land use and energy production.
What is on offer?
This is an i-CASE (industry partnership) studentship for entry in October 2024.
Join us and you will receive a 4-year, funded PhD programme of research and skills training, with cross-disciplinary supervision, plus a structured programme of cohort-wide training and networking events. A highlight is the annual symposium, which is planned and delivered by students.
A unique part of your training will be a fully-funded placement of at least 3 months with the industry partner.
How to apply – Expression of Interest
Students may apply for up to three projects anywhere in the Doctoral Training Partnership (DTP). Applications will be to the DTP centrally, using an online Expression of Interest (EoI). The EoI will include:
§ CV information; not submitted separately
§ Equality, Diversity and Inclusion (EDI) data
§ Names of two referees
Deadline for EoIs is midnight Sunday 7th January 2024.
Submit EoIs using this link: https://leeds.onlinesurveys.ac.uk/white-rose-bbsrc-dtp-expression-of-interest-form
Shortlisted candidates will be required to make formal applications to the Graduate School at each institution, supplying the necessary paperwork.
Details of the interview process will be decided by the academic and industry partners for this project