Streptomyces bacteria habour an incredible arsenal of degradative enzymes. Among them lytic polysaccharide monooxygenases (LPMOs) have emerged as key enzymes of interest within the biomass degradation field. LPMOs are also increasingly being recognized as having functions beyond the breakdown of cellulose and chitin, however these new functions are poorly understood in bacteria. This range of activities has not yet been expanded in bacteria. This project aims to build on our understanding of LPMO biochemistry by focusing on the genetic landscape and redundancy of genes that have been observed for these enzymes within Streptomyces genomes. The successful candidate will bioinformatically and genetically characterize genes of interest from within Streptomyces species to evaluate their functionality in vivo and structurally and biochemically characterize the enzymes that they encode. The outcomes from the project will enhance our understanding of this exciting family of enzymes whilst also offering the opportunity to provide novel enzymatic tools for exploitation in industry.
This studentship is part of the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology. (https://www.whiterose-mechanisticbiology-dtp.ac.uk/). Appointed candidates will be fully-funded for 4 years. The funding includes:
Tax-free annual UKRI stipend (£15,609 for 2021/22 starts. Awards increase every year, typically with inflation).
UK tuition fees (Around £4,500 per year)
Research Training and Support Grant (RTSG)
Conference and Professional Internships for PhD Students (PIPS) allowances
We aim to support the most outstanding applicants from inside and outside the UK. We are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.
How to apply
Applicants should complete an online application form and attach the following documentation to support their application.
- a full academic CV
- degree certificate and transcripts of marks
- Evidence that you meet the University's minimum English language requirements (if applicable).
To help us identify that you are applying for this studentship project please ensure you provide the following information on your application form;
- Select PhD in Biological Sciences as your programme of study
- Give the full project title and name the supervisors listed in this advert
- For source of funding please state you are applying for a White Rose BBSRC DTP funded studentship