Are you keen to progress research in glycoscience at the interface between chemistry, neurobiology and physics?
Perineuronal nets (PNNs) are specialised extracellular matrix structures on the surface of neurons. They control synapse formation and neuronal plasticity, but the underpinning biochemical and biophysical mechanisms are not well understood. Progress is hampered by the lack of tools to selectively label PNNs and visualise their organisation.
In this project, you will combine bio-conjugation techniques and advanced protein biochemistry to engineer multivalent probes that recognise specifically the glycan antigens overexpressed in PNNs. You will design and develop 'superselective' molecular probes that recognise PNNs whilst minimising interference by the other brain extracellular matrix structures. You will also use state-of-the-art biophysical and cell biology techniques to evaluate superselective recognition of PNN-bearing model surfaces and neurones.
If successful, this project will provide a new tool to progress our fundamental understanding of neurobiology. In the future, it may also help tackle neurological disorders such as Alzheimer's disease or schizophrenia.
This project is supported by a multi-disciplinary team of supervisors with expertise in all research areas relevant to this project. Applicants are encouraged to contact the supervisors for more information on this project.
This studentship is part of the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology. (https://www.whiterose-mechanisticbiology-dtp.ac.uk/). Appointed candidates will be fully-funded for 4 years. The funding includes:
Tax-free annual UKRI stipend (£15,609 for 2021/22 starts. Awards increase every year, typically with inflation).
UK tuition fees (Around £4,500 per year)
Research Training and Support Grant (RTSG)
Conference and Professional Internships for PhD Students (PIPS) allowances
We aim to support the most outstanding applicants from inside and outside the UK. We are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.
How to apply
Applicants should complete an online application form and attach the following documentation to support their application.
- a full academic CV
- degree certificate and transcripts of marks
- Evidence that you meet the University's minimum English language requirements (if applicable).
To help us identify that you are applying for this studentship project please ensure you provide the following information on your application form;
- Select PhD in Biological Sciences as your programme of study
- Give the full project title and name the supervisors listed in this advert
- For source of funding please state you are applying for a White Rose BBSRC DTP funded studentship