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  White Rose BBSRC DTP studentship: Elucidating the role of host cell ncRNAs in virus replication


   Faculty of Biological Sciences

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  Prof A Whitehouse, Dr A Macdonald  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Non-coding RNAs (ncRNAs) are critical regulators of gene expression and their importance is emphasised as ncRNAs are frequently altered in many human diseases. Viruses have evolved ways to manipulate host ncRNAs to enhance virus gene expression and modulate the host response to infection. However, how and why ncRNA levels are altered during infection is yet to be fully elucidated.

This project will investigate a novel mechanism utilised by viruses to dysregulate a recently identified group of ncRNAs, termed tRFs. The project will elucidate how and why this emerging ncRNA species are altered by the virus and also determine if reversing this dysregulation can be used as a novel antiviral strategy.

The project is highly novel utilising a multidisciplinary approach and cutting-edge methodology including CLASH, RNA-IPs, imaging, cell biology and 3D tumour models.

In summary, this project will identify novel ways viruses manipulate the host cell to enhance their replication and provide a better understanding of how ncRNA species can regulate gene expression and how this impacts on human disease. Moreover, it may provide new strategies for therapeutic interventions of important human pathogens.

Funding Note

This studentship is part of the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology. (https://www.whiterose-mechanisticbiology-dtp.ac.uk/). Appointed candidates will be fully-funded for 4 years. The funding includes:

Tax-free annual UKRI stipend (£15,609 for 2021/22 starts. Awards increase every year, typically with inflation).

UK tuition fees (Around £4,500 per year)

Research Training and Support Grant (RTSG)

Conference and Professional Internships for PhD Students (PIPS) allowances

We aim to support the most outstanding applicants from inside and outside the UK. We are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.

Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.

How to apply

Applicants should complete an online application form and attach the following documentation to support their application. 

  • a full academic CV
  • degree certificate and transcripts of marks
  • Evidence that you meet the University's minimum English language requirements (if applicable).

To help us identify that you are applying for this studentship project please ensure you provide the following information on your application form;

  • Select PhD in Biological Sciences as your programme of study
  • Give the full project title and name the supervisors listed in this advert
  • For source of funding please state you are applying for a White Rose BBSRC DTP funded studentship
Biological Sciences (4)

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 About the Project