About the Project
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.
Winners versus Losers: Harnessing Cell Competition to kill tumour cells
A key problem in the treatment of cancer is the acquired resistance of the cancer cells to bypass the cell death programmes. It is now clear that cell death acts as part of a quality-control and repair mechanism that eliminates potentially harmful cells, and failure to do so is linked to cancer. Moreover, the reason for late relapse is that anti-cancer therapy for cancer is only partially effective. While tumour proliferation may be suppressed, in many cases disseminated cells survive and subsequently progress. Clearly, treatment efficiency critically depends on the ability of the anti-cancer strategy to trigger cancer cell death.
It is now clear that dying cancer cells play an active role in the initiation of an anti-cancer immune response. However, a cell can die through different cell death pathways, and not every pathway can stimulate an anti-tumour immune response. The emergence of a multitude of cell death mechanisms has shed new light on multiple molecular cross-talks between cell death pathways and innate immune pathways, and revealed new layers of complexity in the relationship between dying cells, adaptive responses and induced immunity.
The successful candidate will use interlocking cell biological, biochemical and genetic approaches to identify and understand the processes that regulate cell death, inflammation and immune homeostasis, and how this knowledge can be used to mobilise a patient’s own immune system against cancer.
Keywords /Subject Areas:
Immunogenic Cell Death
For details on how to apply using our online recruitment system please see http://icr.ac.uk/phds. Please note we only accept applications via the online application system.
Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Molecular Biology.
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