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Winners versus Losers: Harnessing Cell Competition to kill tumour cells

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  • Full or part time
    Prof P Meier
    Dr S Linardopoulos
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.

Winners versus Losers: Harnessing Cell Competition to kill tumour cells

Project Description:
Cell competition is an evolutionary conserved quality control process that eliminates suboptimal, but otherwise viable cells, thereby safeguarding tissue fitness and tissue homeostasis. How relative fitness disparities are measured across groups of cells, and how the decision is taken whether a particular cell will persist in the tissue (‘winner cell’) or is killed (‘loser cell’) is not completely understood. This is a key issue as competitive behaviour is exploited by cells with deregulated oncogenes or tumour suppressors, which subsequently expand at the expense of, and with the help from, their cooperating wild-type (WT) neighbours.
We propose an interlocking cell biological, biochemical and genetic approach to delineate cell competition in mammals, and investigate how this could be exploited to kill cancerous winner cells.

Keywords /Subject Areas:
Cancer
Immunogenic Cell Death
Metabolism
Cell Biology
Cell Competition

Funding Notes

Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world.
See icr.ac.uk/phds to apply
Applications close 11:55pm UK time on Sunday 17th November 2019
Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Molecular Biology.



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