(WIS) NDE1-regulated networks in the developing human brain in health and disease

NDE1 is a nuclear protein that is involved in a wide array of brain diseases ranging between severe brain malformations to schizophrenia. Despite its prominent importance in the developing brain, our information regarding the nuclear activities of this proteins is rudimentary. Here we propose to characterize the NDE1 regulatory network and to validate the derived model in human brain organoids. Our studies will result in better understanding of the molecular changes occurring at early brain development in case of NDE1-associated diseases and can pinpoint to potential therapeutic targets.

Entry Requirements:
Applications should be submitted online and candidates should make direct contact with the Manchester supervisor to discuss their application directly. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.