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(WIS) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation

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  • Full or part time
    Prof Mark Ashe
    Prof C M Grant
    Prof G D Pavitt
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The glycolytic pathway is critical for almost all living systems playing key roles in cancer, diabetes and various human genetic diseases. As such, cells devote huge resources to the production of the glycolytic enzymes and their regulation. Our recent studies show that the mRNAs encoding the glycolytic enzymes are co-ordinately localised and translated into protein at specific sites or factories in the cytoplasm of cells. However, virtually nothing is known regarding the mechanism of this coordinated regulation of mRNA fate. Therefore, in this project we will use yeast as a simple eukaryotic model system to dissect this mechanism examining the production of mRNAs and their export from the nucleus to identify when in the life of a glycolytic mRNA its fate is coordinated with other mRNAs encoding glycolytic enzymes. We aim to identify cis-acting sequences and factors involved in this process. Finally, the project will extend into human cells to test key mechanistic predictions from the yeast system.

Entry Requirements:
Applications should be submitted online and candidates should make direct contact with the Manchester supervisor to discuss their application directly. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject

Funding Notes

This project is to be funded under The University of Manchester and Weizmann Institute of Science Studentship. Funding covers fees (UK/EU rate) and stipend for four years. Candidates will be required to split their time between Manchester and Israel, as outlined on https://www.bmh.manchester.ac.uk/study/research/funded-programmes/weizmann-studentships/

As an equal opportunities institution, we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.



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