About the Project
This project will take a novel interdisciplinary approach to understand the fundamental mechanism of how cytokine receptors modulate HSC fate choice. It studies single molecules in single HSCs, leveraging new technologies/approaches in quantitative and biophysical biology, applying them to functionally defined mouse and human HSCs.
Current funded research provides expertise in biophysics and bioengineering in addition to core strengths in HSC biology (Kent) and cytokine signaling (Hitchcock). Both the Kent and Hitchcock groups have a strong track record of successful interdisciplinary projects, applying new technologies to address fundamental biological questions in HSC biology (Nature, 2018) and cytokine receptor signaling (Science, 2020). The labs are funded by the ERC, MRC, CRUK, Blood Cancer UK, and the Bill and Melinda Gates Foundation.
The project involves cellular and molecular characterisation of HSCs. Techniques will include stem cell transplantation, flow cytometry, RNA-sequencing and super-resolution single molecule microscopy.
The White Rose DTP in Mechanistic Biology is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.
Tax-free annual UKRI stipend (£15,285 for 2020/21)
UK tuition fees (£4,473 for 2021/22)
Research support and training charges (RSTC)
We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
START DATE: 1st October 2021
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