About the Project
The proposed project aims to define how the different domains of LTA and the amphiphilic nature of this molecule contribute to interactions that have a biological impact. You will use cutting-edge chemical biology methods to generate novel tools enabling the study of LTA interactions at the molecular level. Your first aim is to design LTA analogues able to dissect mechanisms using well-characterised cell lines. Interactions will be studied using combination of flow cytometry, imaging and biochemical techniques, and biological impact will be tested with routine LTA-stimulation cell assays.
This project offers a unique opportunity to gain advanced interdisciplinary training, applying cutting-edge developments in chemistry to tackle challenging biological questions. Supported by the combined expertise in immunobiology and chemical glycobiology from the supervisors’ research groups, the student will develop scientific skills in areas of molecular cell biology and biochemistry that will enable to characterise the biological significance of LTA multiple interactions. This project should rapidly generate valuable findings leading to a better understanding of mechanisms supporting microbe/host interplay.
The White Rose DTP in Mechanistic Biology is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.
Tax-free annual UKRI stipend (£15,285 for 2020/21)
UK tuition fees (£4,473 for 2021/22)
Research support and training charges (RSTC)
We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
START DATE: 1st October 2021
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