Supervisory Team: W.S. Brocklesby, J.G. Frey (Chemistry), K. Deinhardt (Biological sciences)
Project description
Within the healthy brain, neurons form large, highly controlled communication networks with multiple other cells. Study of the structure of neurons on a scale less than 100 nm is challenging. Within our research group we have developed an ultrafast coherent soft X-ray source, based on a high-energy femtosecond pulsed laser, which can be used for high resolution imaging at the nanometer scale, and we have demonstrated the first ever application of such a source to biological structures. The new technique of coherent X-ray imaging uses a combination of femtosecond X-ray pulses and sophisticated computational algorithms to calculate images from X-rays scattered from the object as the X-ray beam is moved, known as ptychography.
The aim of this studentship is to interweave the multi-disciplinary strands of X-ray physics, ptychographic image analysis and neuroscience in order to observe neuronal structures at a resolutions of 50nm and below, which will allow us to study fundamental functions and uncover pathological mechanisms and early morphological changes, such as those which can cause neurodegenerative diseases.
The student will benefit from the multi-disciplinary nature of their supervisory team, and act as a point of crystallisation for the application of nanometre-resolution imaging technologies to the nanometre-scale neuronal molecular machines whose properties are fundamental to brain function. The student will gain experience in high-energy femtosecond lasers, confocal fluorescence microscopy techniques, and development and application of ptychographic image reconstruction algorithms. Dependent on funding, the project may extend to work with the Rosalind Franklin Institute, one of the UK’s leading research institutes in the area of biological imaging.
Entry Requirements
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).
Closing date: Applications are accepted throughout the year and several start dates throughout the year are possible. Applications for the typical Sept./Oct. 2023 start should be received no later than 31 August 2023.
Funding: For UK students, Tuition Fees and a stipend of £20,000 tax-free per annum for up to 3.5 years.
How To Apply
Apply online: PhD Application | Research | University of Southampton. Select programme type (Research), 2023/24, Faculty of Physical Sciences and Engineering, next page select “PhD ORC (Full time)”. In Section 2 of the application form you should insert the name of the supervisor Bill Brocklesby
Applications should include:
Curriculum Vitae
Two reference letters
Degree Transcripts/Certificates to date
For further information please contact: [Email Address Removed]
The Zepler Institute is committed to promoting equality, diversity inclusivity as demonstrated by our Athena SWAN award. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance. The University of Southampton is committed to sustainability and has been awarded the Platinum EcoAward.
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