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Ynone trifluoroborate salts: Versatile reagents for organic synthesis


Department of Chemistry

About the Project

We have recently developed a new class of functionality rich intermediates based on ynone trifluoroborate salts. These compounds can be elaborated in multiple ways e.g. via conjugate addition, carbonyl condensation and cross-coupling reactions. This project will seek to establish new synthetic approaches to these intermediates that improves their scope and applicability in organic chemistry. In addition, the further elaboration of these compounds towards medicinal chemistry relevant boronic acid intermediates will also be explored.

Funding Notes

This is a self-funded project.
If you have the correct qualifications and access to your own funding, either from your home country or your own finances, your application to work with this supervisor will be considered.
The applicant should have, or expect to gain, at least an upper second class degree or equivalent overseas qualification in a relevant subject.

References

For leading references see: Org. Lett, 2018, 20, 198.

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