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University of Oxford, Radcliffe Department of Medicine PhD Projects, Programs & Scholarships

We have 45 University of Oxford, Radcliffe Department of Medicine PhD Projects, Programs & Scholarships

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  Academic Endocrine Unit: investigating the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
University of Oxford Radcliffe Department of Medicine
  Prof R Thakker, Dr K Lines, Dr M Stevenson, Dr K Kooblall
Application Deadline: 26 July 2019
Other Potential Supervisors. Dr Asha Bayliss. The Academic Endocrine Unit investigates the molecular basis of endocrine and metabolic disorders that principally affect calcium and phosphate homeostasis.
Details
Type/Funding
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
University of Oxford Radcliffe Department of Medicine
  Dr S Hyde, Dr D Gill
Application Deadline: 26 July 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
Details
Type/Funding
  B cell development and immune regulation: understanding B cell development and diseases associated with abnormal antibody production
University of Oxford Radcliffe Department of Medicine
  Prof R Cornall, Prof S Davis
Application Deadline: 26 July 2019
Our aims are to understand B cell development and diseases associated with abnormal antibody production. Inadequate or excessive immune responses lead to immunodeficiency or autoimmune and inflammatory diseases, which place a major economic and social burden on world health and the quality of human life.
Details
Type/Funding
  Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
University of Oxford Radcliffe Department of Medicine
  Prof C Lygate, Dr S Zervou
Application Deadline: 26 July 2019
Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
Details
Type/Funding
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
University of Oxford Radcliffe Department of Medicine
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
Details
Type/Funding
  Circadian control of energy metabolism and inflammation: Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology
University of Oxford Radcliffe Department of Medicine
  Prof D Ray
Application Deadline: 26 July 2019
Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology.
Details
Type/Funding
  Clinical Genetics: Building the skull – normal and abnormal development
University of Oxford Radcliffe Department of Medicine
  Prof A Wilkie, Dr S Twigg
Application Deadline: 26 July 2019
Working closely with the craniofacial teams based in Oxford and other UK units, we specialise in the application of whole exome and genome sequencing to children born with a serious malformation of the skull termed craniosynostosis.
Details
Type/Funding
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
University of Oxford Radcliffe Department of Medicine
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019
De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
Details
Type/Funding
  Development of Gene Therapy and Gene Editing for Lung Disorders: the translation of new gene therapies to the clinic, including the development of new vectors, and evaluation in animal models of disease.
University of Oxford Radcliffe Department of Medicine
  Dr D Gill, Dr S Hyde
Application Deadline: 26 July 2019
The Gene Medicine Research Group is based in the John Radcliffe Hospital and is focused on the development of new gene therapeutics for lung diesases.
Details
Type/Funding
  Development of the hematopoietic/ immune system in the embryo: obtaining a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development
University of Oxford Radcliffe Department of Medicine
  Prof M DeBruijn
Application Deadline: 26 July 2019
Development of the hematopoietic/ immune system in the embryo. Our aim is to obtain a mechanistic insight into the birth of hematopoietic stem and progenitor cells in embryonic development and determine the contribution of these cells to the emerging hematopoietic and immune systems of the embryo.
Details
Type/Funding
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