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University of Birmingham, School of Biosciences PhD Projects, Programmes & Scholarships
We have 17 University of Birmingham, School of Biosciences PhD Projects, Programmes & Scholarships
We have 17 University of Birmingham, School of Biosciences PhD Projects, Programmes & Scholarships
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Structure and function of Batten disease proteins
The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more
Structural plasticity and regeneration in the Drosophila brain
Does the brain change as we go through life and does this depend on our experiences? What is the impact in the brain of stimulation, activity, exercise… Read more
Using novel ferronucleosides to study and regulate DNA replication in cells
Background. Replication of nucleic acid polymers like DNA is an essential process for all known forms of life. Furthermore, dysregulation and errors in DNA-replication are strongly linked with human diseases including cancer, as well as the process of cellular ageing. Read more
Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage. Read more
Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins
Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
Research Group:
BBSRC MIBTP
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive. Read more
Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
Research Group:
BBSRC MIBTP
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying. Read more
Mechanisms of growth and virulence in Mycobacterium tuberculosis and other pathogenic mycobacteria
Sequenced genomes of mycobacteria, including the human tuberculosis causing pathogen Mycobacterium tuberculosis, reveal a number of genes dedicated to lipid biosynthesis and transport. Read more
Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
Research Group:
BBSRC MIBTP
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017). Read more
Elucidating the mechanisms of outer membrane biogenesis in Gram-negative bacteria
The emergence of bacteria that are resistant to available antibiotics represents an enormous and growing global threat requiring new targets and strategies to combat infection. Read more
Do redox regulated post translational modifications lead to catalase moonlighting?
Reactive oxygen species (ROS) and ROS processing enzymes and proteins have been co-opted during evolution into the regulation of plant growth, development and defence. Read more
Determining novel molecular regulators of necrosis controlling premature cell death
Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases. Read more
BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
Research Group:
BBSRC MIBTP
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more
An interdisciplinary approach to tackling the problem of late Myeloma diagnosis.
There are two parallel studentships on offer. One (this project) is a wet lab project and the other is a bioinformatics project. Both are addressing the fact that multiple myeloma (MM) (a blood cancer of antibody producing cells) is nearly always diagnosed late. Read more
A combined bioinformatic and health economic approach to tackling the problem of late Myeloma diagnosis.
There are two parallel studentships on offer. This one is a bioinformatics-based project. The other (separate FindaPhD entry) is a wet lab project. Read more
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