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University of Bristol, School of Cellular and Molecular Medicine PhD Projects, Programmes & Scholarships
We have 11 University of Bristol, School of Cellular and Molecular Medicine PhD Projects, Programmes & Scholarships
We have 11 University of Bristol, School of Cellular and Molecular Medicine PhD Projects, Programmes & Scholarships
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Survival and adaptation of the meningococcus in aerosol droplets
Abstract. Meningococcal bacteria (Neisseria meningitidis) remain an important cause of meningitis and septicaemia worldwide. Although many people make a good recovery following meningococcal infection, some will be left with life-long disabilities and others will die. Read more
Role of T and NK-cell immunity during dengue virus infection and impact of immune modulation during therapy
A PhD position is available to study the role of human T and NK-cell immunity during infection with dengue virus (DENV), a flavivirus that is transmitted by infected Aedes mosquitoes. Read more
Integrated multi-omics characterisation of human retroviral reservoirs
About the Project. Human retroviruses are a group of pathogens infecting an estimated 50 million people worldwide. The most widespread human retrovirus is HIV-1, which remains a major cause of morbidity and mortality, particularly in developing countries. Read more
Harnessing cell competition to boost tissue repopulation in stem cell therapies
Cell competition is a fundamental biological process akin to natural selection at the cellular level. Through this selection process, cells that are relatively less fit, mis-specified or that harbour some oncogenic mutations are eliminated, and hence called losers, when in proximity of fitter cells, termed winners. Read more
Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Interplay between environmental toxins and cancer predisposition
Cancer arises in part from intrinsic molecular and cellular alterations. For instance, loss of major DNA damage response genes such as BRCA1/2 has long been known to predispose individuals to multiple cancer types. Read more
Mechanisms of cancer cell invasion
Epithelial cancers such as breast cancer become difficult to treat when they invade the surrounding tissues, eventually entering the blood stream and spreading to other parts of the body to form metastases. Read more
MscR: Identification of effective drug combinations to inhibit SARS-CoV-2 variants of concern
Keywords. Bristol, Virology, SARS-CoV-2, Antivirals. Variants of concern remain a public health threat associated with SARS-CoV-2 infection. Read more
MscR: Identifying molecular mechanisms and strategies to control cell competition in tissues
Cell competition is a fundamental biological process akin to natural selection at the cellular level that controls tissue colonisation in healthy tissues and in disease conditions, such as cancer. Read more
MscR: Understanding tumour immune suppression using three-dimensional tumour target cell culture
Cytotoxic T cells have the potential to effectively kill tumour target cells. However, in the tumour microenvironment this potential is substantially suppressed. Read more
MScR: Role of the Rho GTPase RhoD in breast cancer
Epithelial cancers such as breast cancer become difficult to treat when they invade the surrounding tissues, eventually entering the blood stream and spreading to other parts of the body to form metastases. Read more
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