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University of Manchester, School of Chemistry PhD Projects, Programs & Scholarships

We have 58 University of Manchester, School of Chemistry PhD Projects, Programs & Scholarships

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  (A*STAR) Awakening natural product biosynthetic gene clusters for novel compound discovery using systems and synthetic biology
  Prof E Takano, Prof R Breitling
Application Deadline: 31 January 2019
Recent advances in molecular biology, in particular our improved ability to read and (most importantly) write genomic sequences, have led to renewed excitement in the area of genetic engineering.
  (A*STAR) Bacterial glycosyltransferases for bioengineering of biologics
  Prof S Flitsch, Prof P Barran
Application Deadline: 31 January 2019
Within industry, biologics are usually produced in large bioreactors which are subject to slight manufacturing changes in production and purification which induce variations in glycosylation.
  (A*STAR) Synthetic human genomes
  Prof P Cai, Prof D Delneri
Application Deadline: 31 January 2019
We are entering the exciting new age of synthetic biology. Recent technological breakthroughs present big opportunities in synthesizing DNA from scratch, building DNA into radically designed genomes, editing genes within living cells, and investigating how new biological functions emerge from these massive changes.
  (BBSRC DTP CASE) A synthetic biology approach to develop bacterial protein expression tools
  Prof J Micklefield, Dr A Green
Application Deadline: 31 January 2019
Streptomyces and related bacteria possess diverse biosynthetic pathways that produce a wide array of bioactive natural compounds including antibiotics, anti-cancer agents and other therapeutically important molecules.
  (BBSRC DTP CASE) Driving enzymatic carboxylation using supercritical CO2
  Prof D Leys, Dr S Hay, Prof I Larrosa
Application Deadline: 31 January 2019
The use of CO2 as a chemical feedstock is attractive for various reasons, not least as a means to address the desirable reduction of global CO2 levels.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable biomolecules
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2019
The US Food and Drug Administration (FDA) have recommended that many human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
  (BBSRC DTP CASE) Extreme chassis engineering: establishing a generic methodology for the intelligent engineering of biological hosts for the production of high-value chemicals and materials
  Prof R Breitling, Prof E Takano
Application Deadline: 31 January 2019
The ambition of this project is to establish a generic methodology for the intelligent engineering of biological hosts for the production of high-value chemicals and materials.
  (BBSRC DTP CASE) High Pressure Biocatalysis: generating generic and scalable approaches to biocatalysis using engineered enzymes
  Dr S Hay, Prof A Munro
Application Deadline: 31 January 2019
Oxidation reactions play a key role in the bulk chemical industry and enzyme-mediated biocatalysis offers an alternative to the use of traditional catalysts, which can suffer from poor chemical selectivity and require the use of harsh reaction conditions and produce hazardous waste products.
  (BBSRC DTP CASE) Microbial chassis engineering for next generation hydrocarbon biofuels manufacturing
  Prof N Scrutton, Dr H Toogood
Application Deadline: 31 January 2019
The development of economically viable microbial biofuels is a consequence of global concerns about reducing carbon emissions, dwindling fossil fuel supply and the development of cost effective renewable and sustainable bio-based strategies.
  (BBSRC DTP CASE) Native Mass Spectrometry approaches for Electron and Photon mediated Top Down Sequencing of Biotherapeutics
  Prof P Barran, Dr B Bellina
Application Deadline: 31 January 2019
In this project we propose to develop electron and photon mediated top-down sequencing methods to analyse recombinant biological therapeutics including monoclonal antibodies (mAbs) and adeno-associated viral (AAV) vectors.
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