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University of Sheffield, School of Clinical Dentistry PhD Projects, Programs & Scholarships

We have 11 University of Sheffield, School of Clinical Dentistry PhD Projects, Programs & Scholarships

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  ’Follow my leader’: in vitro studies of oral cancer cell motility
  Dr S Whawell, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

Oral cancer cell invasion is a crucial step in the progression of the disease and is mediated by interactions with the extra cellular matrix and factors released by the tumour cells as well as cells that occupy the tumour microenvironment (stroma).
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  Characterisation of the genotype and phenotype of epithelial cells invaded by the periodontal pathogen Porphyromonas gingivalis.
  Dr S Whawell, Dr G Stafford
Applications accepted all year round

Funding Type

PhD Type

The presence of the Gram negative anaerobe Porphyromonas gingivalis is consistently associated with the more severe forms of periodontal disease and its ability to invade host epithelial cells is thought to be important in the pathogenesis of the disease.
  DETECTION AND ANALYSIS OF METASTATIC AND PRIMARY ORAL CANCERS AND STROMAL FEATURES WITH ADVANCED DEEP LEARNING.
  Dr S A Khurram
Application Deadline: 31 May 2020

Funding Type

PhD Type

Supervisor(s). Dr Ali Khurram (School of Clinical Dentistry, Sheffield), Dr Pavitra Krishnaswamy (I2R, A* Star, Singapore), Professor Nasir Rajpoot (University of Warwick).
  Developing a smart non-antibiotic cerium-containing biodegradable wound dressing for treating chronic ulcers
  Dr I Ortega, Dr J Shepherd
Applications accepted all year round

Funding Type

PhD Type

The treatment of long-term ulcers is becoming a major clinical problem, being currently the fourth biggest cost to the NHS in the UK.
  Does fatty acid uptake by oral cancer cells drive metastasis?
  Dr C Murdoch, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

The cell surface receptor CD36 belongs to a large scavenger receptor family that primarily bind lipid-containing molecules. Until recently their expression was thought to be restricted to macrophages and endothelial cells but recent data suggest that epithelial cancer cells may also express this receptor.
  Exploring the role of OGG1 in fibroblast senescence
  Dr D Lambert, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Fibroblasts are the major cell type of connective tissue. They play a critical role in maintaining the extracellular matrix, the ‘glue’ in which most cells reside, and maintaining normal function of other types of cells such as epithelial and immune cells.
  Modelling the epigenome in oral dysplasia and early invasive carcinoma
  Prof K Hunter, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

The key molecular events which lead to the development of premalignant oral lesions and their progression to oral cancer are still poorly understood.
  Salivary Profile of Children and Young Adults and the Impact of Health and Lifestyle
  Dr L Bingle, Dr S Hunt
Applications accepted all year round

Funding Type

PhD Type

Our population is ageing and we know that globally the number of older individuals is increasing at a greater rate than that of young people.
  The oral microbiome, ROS and the development of oral cancer: a role in Fanconi anemia?
  Prof K Hunter, Dr S Collis
Applications accepted all year round

Funding Type

PhD Type

Many patients with Fanconi Anemia (FA) develop cancers of the mouth, esophagus or anogential region. A number of reasons have been suggested, but the millions of bacteria that are naturally resident in these body sites might be a significant contributory factor.
  The Role of Fusion Genes Tumourigenesis
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Salivary gland tumours are uncommon but have a varied and complex pattern of histopathological features.
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