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We have 27 University of Nottingham, School of Life Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
University of Nottingham, School of Life Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 27 University of Nottingham, School of Life Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Mechanistic understanding and drivers to anti-biofilm benefits in complex microbial models using a novel anti-biofilm technology
Microorganisms contained within a biofilm are much more resistant to desiccation, mechanical removal and the action of biocides and detergents. Read more
Elucidating the Molecular Mechanisms of Action and Resistance of Microbes to Anti-biofilm Lactam Technology
Delivering hygiene solutions around the home and in diverse commercial settings is increasingly problematic, particularly where surfaces are continuously challenged by microbial contamination and particularly by biofilm formation. Read more
Using genome engineering and bioinformatics to understand heterochromatin and centromere function in Schizosaccharomyces pombe and in cancer cells
Centromeres are the DNA sequences on eukaryotic chromosomes that mediate accurate chromosome segregation at both mitotic and meiotic cell divisions. Read more
The role of calcium signalling in regulating of tumour cell behaviour
Metastasis is the major cause of mortality in human cancers, yet we know relatively little of the fundamental biology that underlies the important transition to invasive malignancy. Read more
The use of Drosophila melanogaster to identify novel therapeutic agents for Alzheimer’s disease
Since 2003, our understanding of the causes of Alzheimer’s disease (AD) have improved considerably, however, in that time only one new drug treatment has been approved. Read more
How to build and maintain a 3-dimensional polarised epithelial sheet
We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more
The role of microtubule regulators in the progression of cancer: investigating the link between BRCA2 and depolymerising kinesins.
The mitotic kinesin KIF2C/MCAK regulates microtubule length in the mitotic spindle and plays a role in preventing chromosome-microtubule attachment errors. Read more
Competition and cooperation relationships within human microbial communities.
Typical studies of the human microbiome identify dysbiosis by sampling from healthy individuals, comparing them to individuals with a particular disease state, and reporting changes in the presence and/or abundance of bacterial species. Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
Cancer Neuroscience: Investigating the impact of non-CNS tumours on neuronal plasticity in the brain
Cancer is one of the leading causes of death worldwide, resulting in approximately 18 million new cases and 10 million deaths each year. Read more
Epigenomic transcriptomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases
This project aims to use high throughput sequencing technologies and molecular approaches to understand how RNA epitranscriptomic processes contribute to susceptibility to human disorders of the brain. Read more
A new approach to CRISPR-Cas adaptation and the discovery of host accessory-proteins
Bacteria provide many health benefits and eco-environmental services. Although physically simple, they have a sophisticated immune system, CRISPR-Cas. Read more
Providing insights into the molecular understanding of heart development and the formation of congenital heart defects.
Our research aim is to understand how the heart develops and then how it goes wrong to give rise to congenital heart defects (CHDs). Read more
Coronavirus antagonism of innate immune responses
When a virus infects a host, the innate immune response is activated to control the infection. Therefore, all pathogenic viruses have evolved ways to counteract that response to ensure their replication and transmission to a new host. Read more
Genomic approaches to understanding molluscan parasites
Snails and slugs cause worldwide problems, both in terms of direct damage to crops, and as intermediate vectors for diseases of farm animals and humans (e.g. Read more
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