It is estimated that there are close to 50 million people living with dementia worldwide, and this number is estimated to double every 20 years. Read more
Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more
Protein-based therapeutics have shown remarkable success in modulating extracellular targets; however, effective intracellular delivery remains a key challenge in biotherapeutics. Read more
Lipid nanocapsules (LNCs) are very interesting nanoformulations as they can be made by phase inversion technique (PIT), a scalable method with predictable particle size at the beginning of the preparation process. Read more
To decrease the risk of acute infective exacerbations or flare-ups of their condition, individuals with bronchiectasis and COPD are frequently prescribed long-term oral and inhaled antibiotics. Read more
The student will be involved in an exciting project related to the design, formulation and in vitro/in vivo characterisation of super small drug nanocrystals with specific surface properties to enhance drug accumulation in target tissues, such as the lymphatic or central nervous systems. Read more
Community medical and nursing teams are increasingly called upon to deliver palliative and end-of-life care to terminally ill people living in their own homes and in long-term care settings such as nursing homes. Patients and carers may experience problems in medicines access, and processes can be lengthy and burdensome. Read more
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain barrier (BBB), which limits the efficacy of both conventional and novel therapies at the target site. Read more
Poly(acrylic acid)s (PAA) are widely used as emulsifiers, suspending agents and viscosity enhancers within the pharmaceutical, cosmetic and food industries owing to their low cost and excellent safety profile when administered orally or applied topically. Read more
Implantable medical devices are commonplace in modern medicine (e.g. joint replacements, stents, artificial heart valves, etc.), and are of ever increasing interest in the field of regenerative medicine. Read more
Progress in drug design has led to the development of new molecules. However, the limited ability to selectively deliver these molecules at well-defined dosing regimens remains a significant challenge. Read more
Polymer–drug conjugate (PDCs) therapeutics are pharmacologically active macromolecular constructs comprising at least one therapeutic agent covalently bound to a polymeric carrier. Read more
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