USP17 is over-expressed in a range of primary tumours (NSCLC, breast, colorectal, cervical, ovarian, osteosarcoma) and its depletion blocks the growth, and migration, of cells from all of these cancer types. Read more
Many infections and disease states are closely linked to associated microbiomes, either of the patient themselves or the surrounding clinical environment. Read more
Breast Cancer (BC) is the most common cancer in the UK, accounting for 15% of new cancer cases. There is a significant unmet clinical need to understand why some cancers do not respond to treatment and what drives metastasis. Read more
One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more
Protein therapeutics are an important class of medicines with renowned efficacy in the treatment of several relevant disorders. Despite significant advantages, protein delivery remains a significant challenge. Read more
Cochlear implants are implanted electronic hearing device designed to produce useful hearing sensations to persons with severe to profound nerve deafness by electrically stimulating nerves inside the inner ear. Read more
Malaria is a life-threatening infectious disease caused by the plasmodium protozoan parasite passed through the bites of infected female Anopheles mosquitoes. Read more
The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more
Delivery of drug molecules to treat visually impairing ocular diseases that originate in the posterior segment of the eye, has been the most challenging task to the pharmaceutical scientists and retinal specialists. Read more
Antibiotic-resistant bacteria are a growing problem in the 21st century, causing longer and more serious infections, and resulting in poor outcomes for vulnerable patients. Read more
Glioblastoma is an aggressive brain tumour with the median survival time of ~15 months and the 5 year survival rates for those over 50 at a mere 6% (American Cancer Society). Read more
One in two people will develop cancer in their lifetime and it is a leading cause of death. While significant progress has been made in the treatment of some cancers, there still remain some forms of the disease with limited treatment options and poor outcome. Read more
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